You can develop a program containing different combinations of keyboard shortcuts (like ctrl\ or alt? etc.), and then you can use pynput python library to track keyboard keys and once it matches a certain pattern you can execute python programs using OS method.

To make it more efficient you can try running a VBS script that will execute a bat file which will then execute your python code.

Below are my old article for your reference

https://levelup.gitconnected.com/dont-buy-alexa-build-your-own-3967222f2ca8

https://medium.com/p/330be0c288ac

And my github repo for similar code you are looking for https://github.com/Abhayparashar31/karl

These are old articles, repo so don't be mad if u see some errors. 😉